Protein Modification Reagents
Biotium Insulin(E2-E3), Biotin conjugate, 0.1mg/mL
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have
Medchemexpress LLC Propargyl-PEG6-N3 | 1198080-03-3 | MFCD31561110 | >98.0% | C15H27N3O6 | 10MG
Propargyl-PEG6-N3 is a PEG-based linker that contains an azide and a terminal propargyl (alkyne) group, designed for click chemistry and bioconjugation. It is used as a spacer in PROTAC synthesis and in the modular assembly of labeled biomolecules, and should be stored per supplier recommendations.
Medchemexpress LLC Amino-PEG12-Boc | 1383814-00-3 | 98.0% | C31H63NO14 | 100 MG
Amino-PEG12-Boc is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other for a specific target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs exploit the ubiquitin-proteasome system to degrade target proteins